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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-14
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pubmed:abstractText |
Data from studies in patients with nonalcoholic steatohepatitis (NASH) suggest an increased hepatic fatty acid oxidation. We have previously shown higher fasting plasma bile acid concentrations in patients with NASH. In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-activated receptor ? activate fibroblast growth factor 21 (FGF21) and increase hepatic fatty acid oxidation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxybutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/8-hydroxy-2'-deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Bile Acids and Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Ceramides,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyguanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Emulsions,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Oil,
http://linkedlifedata.com/resource/pubmed/chemical/fibroblast growth factor 21,
http://linkedlifedata.com/resource/pubmed/chemical/soybean oil, phospholipid emulsion
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1473-5687
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
382-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21448070-3-Hydroxybutyric Acid,
pubmed-meshheading:21448070-Adult,
pubmed-meshheading:21448070-Alanine Transaminase,
pubmed-meshheading:21448070-Bile Acids and Salts,
pubmed-meshheading:21448070-Blood Glucose,
pubmed-meshheading:21448070-Body Mass Index,
pubmed-meshheading:21448070-Ceramides,
pubmed-meshheading:21448070-Deoxyguanosine,
pubmed-meshheading:21448070-Emulsions,
pubmed-meshheading:21448070-Fatty Acids,
pubmed-meshheading:21448070-Fatty Liver,
pubmed-meshheading:21448070-Female,
pubmed-meshheading:21448070-Fibroblast Growth Factors,
pubmed-meshheading:21448070-Humans,
pubmed-meshheading:21448070-Insulin,
pubmed-meshheading:21448070-Leptin,
pubmed-meshheading:21448070-Male,
pubmed-meshheading:21448070-Middle Aged,
pubmed-meshheading:21448070-Oxidative Stress,
pubmed-meshheading:21448070-Phospholipids,
pubmed-meshheading:21448070-Soybean Oil
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pubmed:year |
2011
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pubmed:articleTitle |
Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis.
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pubmed:affiliation |
Department of Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA. dasaras@ccf.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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