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pubmed:abstractText |
Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes the ?-subunit of the cardiac sodium channel Na(v)1.5. However, ? 20% of probands have SCN5A mutations, suggesting the implication of other genes. MOG1 recently was described as a new partner of Na(v)1.5, playing a potential role in the regulation of its expression and trafficking. We investigated whether mutations in MOG1 could cause BrS.
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