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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-8-1
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pubmed:abstractText |
The inflammatory response in age-related macular degeneration (AMD) is characterized by mononuclear leukocyte infiltration of the outer blood-retina barrier formed by the retinal pigment epithelium (RPE). A key mechanistic element in AMD progression is RPE dysfunction and apoptotic cell loss. The purpose of this study was to evaluate whether monocyte chemoattractant protein (MCP)-1-activated monocytes induce human RPE apoptosis and whether Ca(2+) and reactive oxygen species (ROS) are involved in this process.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6026-34
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pubmed:dateRevised |
2011-9-30
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pubmed:meshHeading |
pubmed-meshheading:21447688-Aged,
pubmed-meshheading:21447688-Aged, 80 and over,
pubmed-meshheading:21447688-Antibodies,
pubmed-meshheading:21447688-Antigens, CD14,
pubmed-meshheading:21447688-Apoptosis,
pubmed-meshheading:21447688-Calcium,
pubmed-meshheading:21447688-Calcium Signaling,
pubmed-meshheading:21447688-Cells, Cultured,
pubmed-meshheading:21447688-Chemokine CCL2,
pubmed-meshheading:21447688-Cyclic ADP-Ribose,
pubmed-meshheading:21447688-Humans,
pubmed-meshheading:21447688-Macular Degeneration,
pubmed-meshheading:21447688-Middle Aged,
pubmed-meshheading:21447688-Monocytes,
pubmed-meshheading:21447688-Reactive Oxygen Species,
pubmed-meshheading:21447688-Retinal Pigment Epithelium
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pubmed:year |
2011
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pubmed:articleTitle |
MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium.
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pubmed:affiliation |
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105-0714, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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