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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1990-10-24
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pubmed:abstractText |
Serum concentrations of CA-15.3, tissue polypeptide antigen (TPA) and mucinous-like carcinoma-associated antigen (MCA) were measured in 327 women: 81 controls, 93 patients with benign breast disease, 46 patients recently diagnosed with breast cancer and 107 patients during breast cancer follow-up. CA-15.3 was elevated in 16% of the controls, in 29% of the patients with benign breast disease, in 65% of the breast cancer patients and in 74% of the follow-up patients. TPA was elevated in 4%, 11%, 36% and 75%, respectively. The corresponding figures for MCA were 10%, 8%, 30% and 64%. The highest sensitivity for cancer detection (74%) was obtained with a combination of CA-15.3 and TPA, while the specificity of this panel was 75%. The negative predictive value of these combined tests was 93%. MCA scored lower values, being only 30% sensitive. The CA-15.3/TPA panel may increase sensitivity compared with single marker tests and provide additional information for clinical evaluation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Tumor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Polypeptide Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/mucinous carcinoma-associated...
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pubmed:status |
MEDLINE
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pubmed:issn |
0959-8049
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
577-80
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2144745-Antigens, Neoplasm,
pubmed-meshheading:2144745-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:2144745-Breast Diseases,
pubmed-meshheading:2144745-Breast Neoplasms,
pubmed-meshheading:2144745-Female,
pubmed-meshheading:2144745-Humans,
pubmed-meshheading:2144745-Peptides,
pubmed-meshheading:2144745-Predictive Value of Tests,
pubmed-meshheading:2144745-Tissue Polypeptide Antigen,
pubmed-meshheading:2144745-Tumor Markers, Biological
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pubmed:year |
1990
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pubmed:articleTitle |
CA-15.3, TPA and MCA as markers for breast cancer.
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pubmed:affiliation |
Biochemistry Department, Lady Davis Carmel Hospital, Haifa, Israel.
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pubmed:publicationType |
Journal Article
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