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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/E2F2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2F2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/E2F7 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/E2F7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/E2f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/E2f7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/TERT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:GünesCagatayC,
pubmed-author:Guguen-GuillouzoChristianeC,
pubmed-author:KumarMukeshM,
pubmed-author:LechelAndreA,
pubmed-author:MeenaJitendra KJK,
pubmed-author:RudolphKarl-LenhardKL,
pubmed-author:SakkVadimV,
pubmed-author:SatyanarayanaAndeA,
pubmed-author:SirmaHüseyinH,
pubmed-author:WeiseJulia MJM,
pubmed-author:WittBrittaB,
pubmed-author:ZenderLarsL
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
326-37, 337.e1-3
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pubmed:meshHeading |
pubmed-meshheading:21447332-Animals,
pubmed-meshheading:21447332-Binding Sites,
pubmed-meshheading:21447332-Cell Differentiation,
pubmed-meshheading:21447332-Cell Proliferation,
pubmed-meshheading:21447332-Cells, Cultured,
pubmed-meshheading:21447332-Chromatin Immunoprecipitation,
pubmed-meshheading:21447332-E2F2 Transcription Factor,
pubmed-meshheading:21447332-E2F7 Transcription Factor,
pubmed-meshheading:21447332-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:21447332-Genes, Reporter,
pubmed-meshheading:21447332-Hepatectomy,
pubmed-meshheading:21447332-Hepatocytes,
pubmed-meshheading:21447332-Humans,
pubmed-meshheading:21447332-Lac Operon,
pubmed-meshheading:21447332-Liver,
pubmed-meshheading:21447332-Liver Regeneration,
pubmed-meshheading:21447332-Male,
pubmed-meshheading:21447332-Mice,
pubmed-meshheading:21447332-Mice, Inbred C57BL,
pubmed-meshheading:21447332-Mice, Transgenic,
pubmed-meshheading:21447332-Promoter Regions, Genetic,
pubmed-meshheading:21447332-RNA Interference,
pubmed-meshheading:21447332-Regulatory Elements, Transcriptional,
pubmed-meshheading:21447332-Retinoblastoma Protein,
pubmed-meshheading:21447332-Telomerase,
pubmed-meshheading:21447332-Time Factors,
pubmed-meshheading:21447332-Transcriptional Activation
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pubmed:year |
2011
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pubmed:articleTitle |
The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.
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pubmed:affiliation |
Heinrich-Pette-Institute, Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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