Linked Life Data

2144604

Source:http://linkedlifedata.com/resource/pubmed/id/2144604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-10-12
pubmed:abstractText
T cell fibronectin (FN) is a product of antigen and mitogen activated human, murine and guinea pig T lymphocytes. Operationally and functionally, T cell FN is a lymphokine associated with delayed hypersensitivity. T cell FN acts at femtomolar concentrations to agglutinate mononuclear phagocytes and translocate monocytes and neutrophils through model extracellular matrices, and is 1.1 x 10(4) to 2.3 x 10(6) times more potent than other FN for these activities. It does not act on peripheral blood lymphocytes. Macrophage agglutination mediated by T cell FN requires cellular metabolism and depends on interactions between multiple classes of cell surface protein receptors and FN gelatin- and cell-binding domains. In contrast, translocation of cells through artificial matrices mediated by T cell FN is a biophysical process dependent on interactions between surface heparan sulfates on responding cells and FN amino-terminal heparin-binding and gelatin-binding domains. The correlation between the ability of cloned murine T cell lines to produce FN and their ability to transfer delayed hypersensitivity reactions suggests that secretion of T cell FN may be an important element in the initiation of these responses. The double activity of T cell FN could allow it to enhance influx of phagocytic effector cells and retain monocytes at tissue sites of T cell activation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-6766
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-47
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
T cell fibronectin: an unexpected inflammatory lymphokine.
pubmed:affiliation
Department of Pathology, New York Medical College, Basic Science, Valhalla.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review