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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-5-3
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pubmed:abstractText |
Carriers of the FMR1 premutation allele are at a significantly increased risk for a late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). The primary features of FXTAS are late-onset intention tremor and gait ataxia. Previous reports have shown global deficits in neuropsychological measures among males with FXTAS, particularly those related to executive functioning. The purpose of this study was to investigate the neuropsychological profile among older males with the premutation who are at risk for FXTAS.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1931-1559
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
404-11
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pubmed:meshHeading |
pubmed-meshheading:21443343-Aged,
pubmed-meshheading:21443343-Aging,
pubmed-meshheading:21443343-Executive Function,
pubmed-meshheading:21443343-Fragile X Mental Retardation Protein,
pubmed-meshheading:21443343-Fragile X Syndrome,
pubmed-meshheading:21443343-Genotype,
pubmed-meshheading:21443343-Heterozygote,
pubmed-meshheading:21443343-Humans,
pubmed-meshheading:21443343-Intelligence,
pubmed-meshheading:21443343-Male,
pubmed-meshheading:21443343-Memory,
pubmed-meshheading:21443343-Middle Aged,
pubmed-meshheading:21443343-Motor Activity,
pubmed-meshheading:21443343-Neuropsychological Tests,
pubmed-meshheading:21443343-Pedigree,
pubmed-meshheading:21443343-Risk Factors,
pubmed-meshheading:21443343-Siblings,
pubmed-meshheading:21443343-Tremor,
pubmed-meshheading:21443343-Trinucleotide Repeat Expansion
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pubmed:year |
2011
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pubmed:articleTitle |
Neuropsychological findings from older premutation carrier males and their noncarrier siblings from families with fragile X syndrome.
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pubmed:affiliation |
Department of Human Genetics, Emory University, Atlanta, GA 30322, USA. emgrave@emory.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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