Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-3-28
pubmed:abstractText
Aging is characterized by a progressive increase in the prevalence of type 2 diabetes mellitus (T2DM), which approaches 20% by age 70 years. Older patients with T2DM are a very heterogeneous group with multiple comorbidities, an increased risk of hypoglycemia, and a greater susceptibility to adverse effects of antihyperglycemic drugs, making treatment of T2DM in this population challenging. The risk of severe hypoglycemia likely represents the greatest barrier to T2DM care in the elderly. Although recent guidelines recommend more flexibility in treating this population with individualized targets, inadequate glycemic control is still closely linked to poor outcome in elderly patients. Incretins (glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1]) are hormones released post-meal from intestinal endocrine cells that stimulate insulin secretion and suppress postprandial glucagon secretion in a glucose-dependent manner. "Incretin therapies," comprising the injectable GLP-1 analogs and oral dipeptidyl peptidase-4 (DPP-4) inhibitors, are promising new therapies for use in older patients because of their consistent efficacy and low risk of hypoglycemia. However, data with these new agents are still scarce in this population, which has not been particularly well represented in clinical trials, highlighting the need for additional specific studies. The objective of this article is to provide an overview of the available data and potential role of these novel incretin therapies in managing T2DM in the elderly. With the exception of the DPP-4 inhibitor vildagliptin, there is no published trial to date dedicated to this population, although a few studies are currently ongoing. Therefore, available data from elderly subgroups of individual studies were also reviewed when available, as well as pooled analyses by age subgroups across clinical programs conducted with incretin therapies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adamantane, http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides, http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidyl-Peptidase IV Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1, http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Incretins, http://linkedlifedata.com/resource/pubmed/chemical/Linaclotide Acetate, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Piperidines, http://linkedlifedata.com/resource/pubmed/chemical/Purines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazines, http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Triazoles, http://linkedlifedata.com/resource/pubmed/chemical/Uracil, http://linkedlifedata.com/resource/pubmed/chemical/Venoms, http://linkedlifedata.com/resource/pubmed/chemical/alogliptin, http://linkedlifedata.com/resource/pubmed/chemical/exenatide, http://linkedlifedata.com/resource/pubmed/chemical/liraglutide, http://linkedlifedata.com/resource/pubmed/chemical/saxagliptin, http://linkedlifedata.com/resource/pubmed/chemical/sitagliptin, http://linkedlifedata.com/resource/pubmed/chemical/vildagliptin
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
2154-8331
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-21
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21441754-Adamantane, pubmed-meshheading:21441754-Age Factors, pubmed-meshheading:21441754-Aged, pubmed-meshheading:21441754-Aging, pubmed-meshheading:21441754-Clinical Trials as Topic, pubmed-meshheading:21441754-Diabetes Mellitus, Type 2, pubmed-meshheading:21441754-Dipeptides, pubmed-meshheading:21441754-Dipeptidyl-Peptidase IV Inhibitors, pubmed-meshheading:21441754-Female, pubmed-meshheading:21441754-Glucagon-Like Peptide 1, pubmed-meshheading:21441754-Humans, pubmed-meshheading:21441754-Hypoglycemic Agents, pubmed-meshheading:21441754-Incretins, pubmed-meshheading:21441754-Male, pubmed-meshheading:21441754-Middle Aged, pubmed-meshheading:21441754-Nitriles, pubmed-meshheading:21441754-Peptides, pubmed-meshheading:21441754-Piperidines, pubmed-meshheading:21441754-Purines, pubmed-meshheading:21441754-Pyrazines, pubmed-meshheading:21441754-Pyrrolidines, pubmed-meshheading:21441754-Quinazolines, pubmed-meshheading:21441754-Treatment Outcome, pubmed-meshheading:21441754-Triazoles, pubmed-meshheading:21441754-Uracil, pubmed-meshheading:21441754-Venoms
pubmed:year
2011
pubmed:articleTitle
Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.
pubmed:affiliation
Pôle de Gérontologie Clinique, Centre Henri Choussat, Hôpital Xavier Arnozan, Bordeaux, France.
pubmed:publicationType
Journal Article, Review