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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0037083,
umls-concept:C0205099,
umls-concept:C0299583,
umls-concept:C1158366,
umls-concept:C1514873,
umls-concept:C1521828,
umls-concept:C1522564,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1710082,
umls-concept:C1882115
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|
pubmed:issue |
5
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|
pubmed:dateCreated |
2011-4-28
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|
pubmed:abstractText |
ob/ob and db/db mice manifest myocardial hypertrophy, insulin resistance, altered substrate utilization, mitochondrial dysfunction, and lipid accumulation. This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db mice in the absence of diabetes and morbid obesity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1939-327X
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
60
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1424-34
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pubmed:meshHeading |
pubmed-meshheading:21441440-Adiponectin,
pubmed-meshheading:21441440-Animals,
pubmed-meshheading:21441440-Body Composition,
pubmed-meshheading:21441440-Caloric Restriction,
pubmed-meshheading:21441440-Fatty Acids,
pubmed-meshheading:21441440-Glucose Tolerance Test,
pubmed-meshheading:21441440-Heart,
pubmed-meshheading:21441440-Injections, Intraperitoneal,
pubmed-meshheading:21441440-Leptin,
pubmed-meshheading:21441440-Male,
pubmed-meshheading:21441440-Mice,
pubmed-meshheading:21441440-Mice, Obese,
pubmed-meshheading:21441440-Microscopy, Electron,
pubmed-meshheading:21441440-Mitochondria,
pubmed-meshheading:21441440-Myocardium,
pubmed-meshheading:21441440-Oxidation-Reduction,
pubmed-meshheading:21441440-Palmitic Acids,
pubmed-meshheading:21441440-Polymerase Chain Reaction,
pubmed-meshheading:21441440-Signal Transduction,
pubmed-meshheading:21441440-Triglycerides
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pubmed:year |
2011
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pubmed:articleTitle |
Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.
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pubmed:affiliation |
Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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