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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-7-4
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pubmed:abstractText |
Acute pancreatitis is characterized by early activation of intracellular proteases followed by acinar cell death and inflammation. Activation of damage-associated molecular pattern (DAMP) receptors and a cytosolic complex termed the inflammasome initiate forms of inflammation. In this study, we examined whether DAMP-receptors and the inflammasome provide the link between cell death and the initiation of inflammation in pancreatitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CIAS1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caerulein,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/IRS 954,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammasomes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Purinergic P2X Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pycard protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X7,
http://linkedlifedata.com/resource/pubmed/chemical/Taurolithocholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr9 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin 1 precursor,
http://linkedlifedata.com/resource/pubmed/chemical/taurolithocholic acid 3-sulfate
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BarratFranckF,
pubmed-author:FlavellRichardR,
pubmed-author:GorelickFredF,
pubmed-author:HoqueRafazR,
pubmed-author:HusainSohailS,
pubmed-author:LuoYuhuanY,
pubmed-author:MalikAhsanA,
pubmed-author:MehalWajahatW,
pubmed-author:SarwarSherhayarS,
pubmed-author:ShahAhsanA,
pubmed-author:SohailMuhammadM
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
358-69
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pubmed:meshHeading |
pubmed-meshheading:21439959-Acute Disease,
pubmed-meshheading:21439959-Animals,
pubmed-meshheading:21439959-Anti-Inflammatory Agents,
pubmed-meshheading:21439959-Apoptosis,
pubmed-meshheading:21439959-Caerulein,
pubmed-meshheading:21439959-Carrier Proteins,
pubmed-meshheading:21439959-Caspase 1,
pubmed-meshheading:21439959-Cytoskeletal Proteins,
pubmed-meshheading:21439959-DNA,
pubmed-meshheading:21439959-Disease Models, Animal,
pubmed-meshheading:21439959-Inflammasomes,
pubmed-meshheading:21439959-Interleukin-1,
pubmed-meshheading:21439959-Macrophages,
pubmed-meshheading:21439959-Male,
pubmed-meshheading:21439959-Mice,
pubmed-meshheading:21439959-Mice, Inbred C57BL,
pubmed-meshheading:21439959-Mice, Knockout,
pubmed-meshheading:21439959-Necrosis,
pubmed-meshheading:21439959-Neutrophil Infiltration,
pubmed-meshheading:21439959-Pancreas,
pubmed-meshheading:21439959-Pancreatitis,
pubmed-meshheading:21439959-Pneumonia,
pubmed-meshheading:21439959-Protein Precursors,
pubmed-meshheading:21439959-Purinergic P2X Receptor Antagonists,
pubmed-meshheading:21439959-RNA, Messenger,
pubmed-meshheading:21439959-Receptors, Purinergic P2X7,
pubmed-meshheading:21439959-Severity of Illness Index,
pubmed-meshheading:21439959-Signal Transduction,
pubmed-meshheading:21439959-Taurolithocholic Acid,
pubmed-meshheading:21439959-Toll-Like Receptor 9
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pubmed:year |
2011
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pubmed:articleTitle |
TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis.
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pubmed:affiliation |
Section of Digestive Diseases, Department of Pediatrics, Yale University, New Haven, Connecticut 06520-8019, USA.
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pubmed:publicationType |
Journal Article
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