| pubmed-article:21439958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C1865344 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21439958 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21439958 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:21439958 | pubmed:dateCreated | 2011-5-9 | lld:pubmed |
| pubmed-article:21439958 | pubmed:abstractText | Estrogen plays an important role in maintaining bone density in women. Estrogen receptor (ER) is expressed in osteoblasts and osteoclasts; however, the precise mechanism of ER in bone is not fully understood. In the present study, we generated a conditional transgenic mouse caER?(ColI) that expresses the constitutively active ER? in osteoblasts using collagen type I promoter-driven Cre transgenic mice. The caER?(ColI) mice showed increased bone mineral density (BMD). Osteoblasts prepared from caER?(ColI) mice expressed high levels of osteoprotegerin and decreased levels of IL-6, both of which are known to regulate osteoclast differentiation. These results suggest that ER? regulates osteoprotegerin and IL-6 production in osteoblasts and modulates BMD. The conditional transgenic mouse model is useful for understanding the in vivo function of ER?. | lld:pubmed |
| pubmed-article:21439958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21439958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21439958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21439958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21439958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21439958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21439958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21439958 | pubmed:month | May | lld:pubmed |
| pubmed-article:21439958 | pubmed:issn | 1873-3468 | lld:pubmed |
| pubmed-article:21439958 | pubmed:author | pubmed-author:IkedaKazuhiro... | lld:pubmed |
| pubmed-article:21439958 | pubmed:author | pubmed-author:InoueSatoshiS | lld:pubmed |
| pubmed-article:21439958 | pubmed:author | pubmed-author:TsukuiTohruT | lld:pubmed |
| pubmed-article:21439958 | pubmed:author | pubmed-author:Horie-InoueKu... | lld:pubmed |
| pubmed-article:21439958 | pubmed:copyrightInfo | Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21439958 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21439958 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:21439958 | pubmed:volume | 585 | lld:pubmed |
| pubmed-article:21439958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21439958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21439958 | pubmed:pagination | 1303-9 | lld:pubmed |
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| pubmed-article:21439958 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21439958 | pubmed:articleTitle | Conditional expression of constitutively active estrogen receptor ? in osteoblasts increases bone mineral density in mice. | lld:pubmed |
| pubmed-article:21439958 | pubmed:affiliation | Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan. | lld:pubmed |
| pubmed-article:21439958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21439958 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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