Source:http://linkedlifedata.com/resource/pubmed/id/21439958
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2011-5-9
|
| pubmed:abstractText |
Estrogen plays an important role in maintaining bone density in women. Estrogen receptor (ER) is expressed in osteoblasts and osteoclasts; however, the precise mechanism of ER in bone is not fully understood. In the present study, we generated a conditional transgenic mouse caER?(ColI) that expresses the constitutively active ER? in osteoblasts using collagen type I promoter-driven Cre transgenic mice. The caER?(ColI) mice showed increased bone mineral density (BMD). Osteoblasts prepared from caER?(ColI) mice expressed high levels of osteoprotegerin and decreased levels of IL-6, both of which are known to regulate osteoclast differentiation. These results suggest that ER? regulates osteoprotegerin and IL-6 production in osteoblasts and modulates BMD. The conditional transgenic mouse model is useful for understanding the in vivo function of ER?.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1873-3468
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
6
|
| pubmed:volume |
585
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1303-9
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| pubmed:meshHeading |
pubmed-meshheading:21439958-Animals,
pubmed-meshheading:21439958-Animals, Newborn,
pubmed-meshheading:21439958-Bone Density,
pubmed-meshheading:21439958-Bone and Bones,
pubmed-meshheading:21439958-Cells, Cultured,
pubmed-meshheading:21439958-Estrogen Receptor alpha,
pubmed-meshheading:21439958-Female,
pubmed-meshheading:21439958-Green Fluorescent Proteins,
pubmed-meshheading:21439958-HeLa Cells,
pubmed-meshheading:21439958-Humans,
pubmed-meshheading:21439958-Immunoassay,
pubmed-meshheading:21439958-Interleukin-6,
pubmed-meshheading:21439958-Male,
pubmed-meshheading:21439958-Mice,
pubmed-meshheading:21439958-Mice, Inbred C57BL,
pubmed-meshheading:21439958-Mice, Transgenic,
pubmed-meshheading:21439958-Microscopy, Fluorescence,
pubmed-meshheading:21439958-Osteoblasts,
pubmed-meshheading:21439958-Osteoprotegerin,
pubmed-meshheading:21439958-Reverse Transcriptase Polymerase Chain Reaction
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Conditional expression of constitutively active estrogen receptor ? in osteoblasts increases bone mineral density in mice.
|
| pubmed:affiliation |
Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|