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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-4-4
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pubmed:abstractText |
A High Throughput Screening campaign allowed the identification of a novel class of ureas as 11?-HSD1 inhibitors. Rational chemical optimization provided potent and selective inhibitors of both human and murine 11?-HSD1 with an appropriate ADME profile and ex vivo activity in target tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:Ben-HassineMajdiM,
pubmed-author:BraunAlainA,
pubmed-author:CrespinOlivierO,
pubmed-author:Dadji-FaïhunRommelR,
pubmed-author:EngelChristianC,
pubmed-author:FarjotGéraldineG,
pubmed-author:GüssregenStefanS,
pubmed-author:LegerCélineC,
pubmed-author:ManianiKarimaK,
pubmed-author:MonseauCatherineC,
pubmed-author:MougenotCécileC,
pubmed-author:MougenotPatrickP,
pubmed-author:NamaneClaudieC,
pubmed-author:NicolaïEricE,
pubmed-author:NoahLionelL,
pubmed-author:OnofriBénédicteB,
pubmed-author:PacquetFrançoisF,
pubmed-author:PascalCécileC,
pubmed-author:PhilippoChristopheC,
pubmed-author:RagotJean-LucJL,
pubmed-author:Van-PhamThaoT,
pubmed-author:VenierOlivierO
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2244-51
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pubmed:meshHeading |
pubmed-meshheading:21439819-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:21439819-Administration, Oral,
pubmed-meshheading:21439819-Animals,
pubmed-meshheading:21439819-Binding Sites,
pubmed-meshheading:21439819-Crystallography, X-Ray,
pubmed-meshheading:21439819-Enzyme Inhibitors,
pubmed-meshheading:21439819-High-Throughput Screening Assays,
pubmed-meshheading:21439819-Humans,
pubmed-meshheading:21439819-Mice,
pubmed-meshheading:21439819-Pyrazoles,
pubmed-meshheading:21439819-Pyrrolidines,
pubmed-meshheading:21439819-Urea
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pubmed:year |
2011
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pubmed:articleTitle |
Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11?-hydroxysteroid-dehydrogenase type 1.
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pubmed:affiliation |
Sanofi-aventis R&D, 1 Avenue Pierre Brossolette, 91385 Chilly-Mazarin, France. Olivier.Venier@sanofi-aventis.com
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pubmed:publicationType |
Journal Article
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