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pubmed-article:21438635pubmed:abstractTextAnalogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16?,17?,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.lld:pubmed
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pubmed-article:21438635pubmed:articleTitleSynthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.lld:pubmed
pubmed-article:21438635pubmed:affiliationInstitute of Chemistry, University of Bia?ystok , Pi?sudskiego 11/4, 15-443 Bia?ystok, Poland.lld:pubmed
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