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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-5-5
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pubmed:abstractText |
Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16?,17?,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1520-4804
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3298-305
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pubmed:meshHeading |
pubmed-meshheading:21438635-Antineoplastic Agents,
pubmed-meshheading:21438635-Apoptosis,
pubmed-meshheading:21438635-Caspase 3,
pubmed-meshheading:21438635-Caspase 7,
pubmed-meshheading:21438635-Cell Cycle,
pubmed-meshheading:21438635-Cell Line, Tumor,
pubmed-meshheading:21438635-Cholestenones,
pubmed-meshheading:21438635-Drug Screening Assays, Antitumor,
pubmed-meshheading:21438635-Enzyme Activation,
pubmed-meshheading:21438635-Fibroblasts,
pubmed-meshheading:21438635-Humans,
pubmed-meshheading:21438635-Saponins,
pubmed-meshheading:21438635-Stereoisomerism,
pubmed-meshheading:21438635-Structure-Activity Relationship
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pubmed:year |
2011
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pubmed:articleTitle |
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
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pubmed:affiliation |
Institute of Chemistry, University of Bia?ystok , Pi?sudskiego 11/4, 15-443 Bia?ystok, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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