rdf:type |
|
lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0010823,
umls-concept:C0013126,
umls-concept:C0021311,
umls-concept:C0026565,
umls-concept:C0035647,
umls-concept:C0039194,
umls-concept:C0205217,
umls-concept:C0205275,
umls-concept:C0264939,
umls-concept:C0332281,
umls-concept:C1332714
|
pubmed:issue |
7
|
pubmed:dateCreated |
2011-6-30
|
pubmed:abstractText |
Expanded populations of CD4+CD28- T cells with a cytotoxic phenotype have been repeatedly reported in patients with granulomatosis with polyangiitis (Wegener's) (GPA). In healthy individuals expansion of this T cell population follows cytomegalovirus (CMV) infection. We undertook this study to investigate whether CMV infection may be responsible for driving the expansion of CD4+CD28- T cells in GPA patients and how this might relate to clinical features.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1529-0131
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright © 2011 by the American College of Rheumatology.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
63
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2127-37
|
pubmed:meshHeading |
pubmed-meshheading:21437878-Adult,
pubmed-meshheading:21437878-Aged,
pubmed-meshheading:21437878-Antigens, CD28,
pubmed-meshheading:21437878-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21437878-Cytomegalovirus,
pubmed-meshheading:21437878-Cytomegalovirus Infections,
pubmed-meshheading:21437878-Female,
pubmed-meshheading:21437878-Humans,
pubmed-meshheading:21437878-Male,
pubmed-meshheading:21437878-Middle Aged,
pubmed-meshheading:21437878-Wegener Granulomatosis
|
pubmed:year |
2011
|
pubmed:articleTitle |
CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality.
|
pubmed:affiliation |
University of Birmingham, Birmingham, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|