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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0021745,
umls-concept:C0033268,
umls-concept:C0034693,
umls-concept:C0039194,
umls-concept:C0041217,
umls-concept:C0085358,
umls-concept:C0333668,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1990-9-27
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pubmed:abstractText |
Sprague-Dawley rats infected with Trypanosoma brucei brucei showed a strong and rapid induction of splenocyte IFN-gamma (within 12 h post-infection) as measured by a single cell assay for IFN-gamma secretion. Depletion of CD8+ cells in infected rats abrogated the IFN-gamma production, suppressed parasite growth and increased survival of the animals. Induction of MHC class I antigens in the paraventricular and supra-optic hypothalamic nuclei caused by the trypanosome infection was also inhibited by the CD8+ cell depletion. It is suggested that the CD8+ cells are involved directly or indirectly in growth regulation of the parasite and that IFN-gamma induced by the parasite may be one of the factors that trigger MHC expression and immunosuppression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-2423637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-2443979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-2455606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-2681260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-3099380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-3131436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-3216412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-3898352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-3932581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-4435838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-46700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6151687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6190591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6411853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6415111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6433204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2143706-6967416
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2143706-Animals,
pubmed-meshheading:2143706-Antibodies, Monoclonal,
pubmed-meshheading:2143706-Histocompatibility Antigens Class I,
pubmed-meshheading:2143706-Hypothalamus,
pubmed-meshheading:2143706-Immunoenzyme Techniques,
pubmed-meshheading:2143706-Immunosuppression,
pubmed-meshheading:2143706-Interferon-gamma,
pubmed-meshheading:2143706-Male,
pubmed-meshheading:2143706-Pituitary Gland, Posterior,
pubmed-meshheading:2143706-Rats,
pubmed-meshheading:2143706-Rats, Inbred Strains,
pubmed-meshheading:2143706-T-Lymphocytes, Regulatory,
pubmed-meshheading:2143706-Trypanosoma brucei brucei,
pubmed-meshheading:2143706-Trypanosomiasis, African
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pubmed:year |
1990
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pubmed:articleTitle |
Depletion of CD8+ T cells suppresses growth of Trypanosoma brucei brucei and interferon-gamma) production in infected rats.
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pubmed:affiliation |
Department of Neurology, Karolinska Institute, Huddinge Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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