Source:http://linkedlifedata.com/resource/pubmed/id/21436290
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2011-4-1
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pubmed:abstractText |
Inflammation contributes to the pathogenesis of ischemic acute kidney injury (AKI), and T cells mediate the early phase of ischemia-reperfusion injury (IRI). The Fas/Fas ligand (FasL) pathway modulates the balance of T cell subsets in the peripheral circulation as well as multiple inflammatory responses, suggesting that FasL may mediate ischemic AKI. Here, we induced bilateral renal IRI in mice bearing a loss-of-function mutation of FasL (the gld mutation) and in wild-type mice. Compared with wild-type mice, serum creatinine was lower in gld mice (1.4 ± 0.9 mg/dl versus 2.6 ± 0.4) at 24 hours after IRI (P<0.05). In addition, gld mice had fewer TNF-?-producing T lymphocytes in the kidneys and renal lymph nodes. Furthermore, pharmacologic blockade of FasL protected the kidneys of wild-type mice from IRI. Analysis of bone marrow chimeric mice suggested that the pathogenic effect of FasL involves leukocytes; reconstitution of wild-type mice with gld splenocytes attenuated IRI. In contrast, reconstitution of gld mice with wild-type splenocytes enhanced IRI. These data demonstrate that FasL, particularly on leukocytes, mediates ischemic AKI.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1533-3450
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pubmed:author |
pubmed-author:HamadAbdel Rahim AAR,
pubmed-author:HigbeeElizabethE,
pubmed-author:HuangYanfeiY,
pubmed-author:JangHye RyounHR,
pubmed-author:KoGang JeeGJ,
pubmed-author:LiuManchangM,
pubmed-author:RabbHamidH,
pubmed-author:RacusenLorraineL,
pubmed-author:WomerKarl LKL,
pubmed-author:XiaoZuoxiangZ,
pubmed-author:YagitaHideoH
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pubmed:copyrightInfo |
Copyright © 2011 by the American Society of Nephrology
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
732-42
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pubmed:meshHeading |
pubmed-meshheading:21436290-Acute Kidney Injury,
pubmed-meshheading:21436290-Animals,
pubmed-meshheading:21436290-Caspase 3,
pubmed-meshheading:21436290-Fas Ligand Protein,
pubmed-meshheading:21436290-Leukocytes,
pubmed-meshheading:21436290-Lymph Nodes,
pubmed-meshheading:21436290-Male,
pubmed-meshheading:21436290-Mice,
pubmed-meshheading:21436290-Mice, Inbred C57BL,
pubmed-meshheading:21436290-Mice, Knockout,
pubmed-meshheading:21436290-Models, Animal,
pubmed-meshheading:21436290-Peroxidase,
pubmed-meshheading:21436290-Reperfusion Injury,
pubmed-meshheading:21436290-Spleen,
pubmed-meshheading:21436290-T-Lymphocytes,
pubmed-meshheading:21436290-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury.
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pubmed:affiliation |
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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