Linked Life Data

21435873

Source:http://linkedlifedata.com/resource/pubmed/id/21435873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-4-4
pubmed:abstractText
Optimization of a water soluble, moderately potent lead series of isoxazole-3-carboxamides was conducted, affording a compound with the requisite balance of potency, solubility and physicochemical properties for in vivo use. Compound 8e was demonstrated to be efficacious in a rat model of inflammatory pain, following oral administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Copyright © 2011. Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2559-63
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Identification of potent, soluble, and orally active TRPV1 antagonists.
pubmed:affiliation
Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. Paul.Ratcliffe@grunenthal.com
pubmed:publicationType
Journal Article