Linked Life Data

2143374

Source:http://linkedlifedata.com/resource/pubmed/id/2143374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-9-10
pubmed:abstractText
Various adenovirus E1a proteins, including 13S protein, 12S protein and three other derivatives of 13S protein with deletions were expressed in Saccharomyces cerevisiae. Both the C-terminal 67 residues and the 13S unique domain are required for the nuclear targeting in yeast. The N-terminus containing multiple functional domains appears to be involved in the G1 arrest of diploid yeast and two other regions, the region containing amino acid residues between 122 and 139, and the 67 residues of the C-terminus are required for the lethal effect on haploid yeast. The latter effect, however, is dependent on strains. Thus, the yeast system may be utilized for functional dissection of E1a protein by further analyzing metabolic consequences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
470-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Strain-specific lethal effect of the adenovirus E1a protein on Saccharomyces cerevisiae.
pubmed:affiliation
Department of Bacteriology, Faculty of Medicine, University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't