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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-5-4
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pubmed:abstractText |
There have been few investigations of the link between changes in life-course socioeconomic position (SEP) and cognitive decline or incidence of dementia. The authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive impairment but not dementia (CIND) over a decade of follow-up. Participants of Mexican origin (n = 1,789) were members of the Sacramento Area Latino Study on Aging cohort. Incidence of dementia/CIND was ascertained by using standard diagnostic criteria. SEP indicators at 3 life stages (childhood, adulthood, and midlife) were used to derive a measure of cumulative SEP (range, 0 to 8) and SEP mobility. Nearly 24% of the sample maintained a low SEP throughout life. Hazard ratios and 95% confidence intervals were computed from Cox proportional hazards regression models. In fully adjusted models, participants with a continuously high SEP had lower hazard ratios for dementia/CIND compared with those with a continuously low SEP at all 3 life stages (hazard ratio = 0.49, 95% confidence interval: 0.24, 0.98; P = 0.04). In age-adjusted models, participants experienced a 16% greater hazard of dementia/CIND with every 1-unit increase in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interval: 1.01, 1.33; P = 0.04). Early exposures to social disadvantage may increase the risk of late-life dementia.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG033751,
http://linkedlifedata.com/resource/pubmed/grant/AG12975,
http://linkedlifedata.com/resource/pubmed/grant/DK60753,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-03S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-06S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-07A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-09,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-10,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-11,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-12A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-13,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012975-14,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK060753-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK060753-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK060753-03,
http://linkedlifedata.com/resource/pubmed/grant/R03 AG033751-01A2
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1476-6256
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1148-58
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:21430188-Age Factors,
pubmed-meshheading:21430188-Aged,
pubmed-meshheading:21430188-Aged, 80 and over,
pubmed-meshheading:21430188-California,
pubmed-meshheading:21430188-Cognition Disorders,
pubmed-meshheading:21430188-Cohort Studies,
pubmed-meshheading:21430188-Confidence Intervals,
pubmed-meshheading:21430188-Dementia,
pubmed-meshheading:21430188-Female,
pubmed-meshheading:21430188-Humans,
pubmed-meshheading:21430188-Incidence,
pubmed-meshheading:21430188-Male,
pubmed-meshheading:21430188-Mexican Americans,
pubmed-meshheading:21430188-Middle Aged,
pubmed-meshheading:21430188-Poverty,
pubmed-meshheading:21430188-Proportional Hazards Models,
pubmed-meshheading:21430188-Risk Factors,
pubmed-meshheading:21430188-Socioeconomic Factors,
pubmed-meshheading:21430188-Survival Analysis
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pubmed:year |
2011
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pubmed:articleTitle |
Life-course socioeconomic position and incidence of dementia and cognitive impairment without dementia in older Mexican Americans: results from the Sacramento area Latino study on aging.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 3333 California Street, Suite 280, San Francisco, CA 94118, USA. adina.zekialhazzouri@ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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