Linked Life Data

21428881

Source:http://linkedlifedata.com/resource/pubmed/id/21428881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2011-4-12
pubmed:abstractText
Post translational modification of histones and non-histone proteins by acetylation play a key role in tumourigenesis. Histone deacetylases (HDACs) are enzymes involved in remodelling of chromatin by deacetylating the lysine residues and play a pivotal role in epigenetic regulation of gene expression. An aberrant activity of HDACs has been documented in several types of cancers and HDACs have emerged as an attractive therapeutic target. HDAC inhibitors (HDACi) are a structurally diverse group of anti-cancer agents which have a potential role in regulation of gene expression and induction of cell death, cell cycle arrest, and differentiation by altering the acetylation status of histone and non-histone proteins. HDACi have pleiotropic effects on malignant cells and have demonstrated potent anti-cancer activity in pre-clinical studies. A number of clinical trials of HDACi as a monotherapy and/or in combination with conventional and novel chemotherapeutic drugs in solid and haematologic tumours have been published with variable efficacy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1875-533X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1658-71
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Developing histone deacetylase inhibitors as anti-cancer therapeutics.
pubmed:affiliation
University of Glasgow, Institute of Cancer Sciences, Cancer Research UK, Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK. balaji.venugopal@glasgow.ac.uk
pubmed:publicationType
Journal Article, Review