Linked Life Data

21428407

Source:http://linkedlifedata.com/resource/pubmed/id/21428407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-4-21
pubmed:abstractText
In vivo imaging of ?-amyloid plaques in the brain may lead to the early diagnosis of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of treatment. In the present study, we report on the development of two potential PET probes, [(18)F]FPYBF-2 ([(18)F]10) and [(18)F]FPHBF-2 ([(18)F]21), for imaging of ?-amyloid plaques in AD brain. In experiments in vitro, 10 and 21 displayed high affinity for A?(1-42) aggregates (K(i) = 2.41 and 3.85 nM, respectively). In biodistribution experiments using normal mice, they displayed high uptake in the brain (7.38 and 8.18%?ID/g at 2 min postinjection, respectively), and the radioactivity washed out from the brain rapidly (3.15 and 3.87%?ID/g at 60 min postinjection, respectively), which is highly desirable for ?-amyloid imaging agents. In vivo, they clearly labeled ?-amyloid plaques in Tg2576 mice. Furthermore, the specific labeling of ?-amyloid plaques by 10 and 21 was observed in autoradiographs of sections of autopsied AD brain. These new fluorinated benzofuran derivatives are promising PET probes for imaging cerebral ?-amyloid plaques.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2971-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Novel 18F-labeled benzofuran derivatives with improved properties for positron emission tomography (PET) imaging of ?-amyloid plaques in Alzheimer's brains.
pubmed:affiliation
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan. ono@pharm.kyoto-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't