Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-8-30
pubmed:abstractText
We studied proliferation and interleukin 2 production by B6 mouse spleen cells in response to stimulation by irradiated cynomolgus monkey spleen cells and compared the results with responses against whole MHC-disparate allogeneic controls (BALB/c). We found that (a) primary xenogeneic helper responses were absent, whereas primary allogeneic responses were brisk, (b) secondary xenogeneic helper responses were dependent on CD4+ T cells and responder antigen-presenting cells (APCs), whereas allogeneic responses could be mediated by either CD4+ or CD8+ T cells independently and were primarily dependent on the presence of stimulator APCs, and (c) secondary xenogeneic helper responses were blocked by an antibody directed against responder class II MHC molecules. These results suggest that mouse helper T cells recognize disparate xenoantigens as processed peptides in association with self class II MHC molecules, similar to the recognition of nominal antigens and unlike direct allo-recognition.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-122872, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-123544, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-134125, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-161967, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2295880, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2419431, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2448379, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2464645, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2477484, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2478616, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2504879, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2543930, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2685171, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2783490, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2786469, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2946773, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2948671, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-2960540, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-3076400, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-3262639, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-3491988, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4106487, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4133595, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4266187, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4392948, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4399155, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4403229, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4427086, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-4890818, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-5011652, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-5022178, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-5065082, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-5113815, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-5804781, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-58457, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-6153237, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-6185618, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-6202762, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-6448810, http://linkedlifedata.com/resource/pubmed/commentcorrection/2142721-6982933
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
567-75
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2142721-Animals, pubmed-meshheading:2142721-Antigen-Presenting Cells, pubmed-meshheading:2142721-Antigens, CD4, pubmed-meshheading:2142721-Cells, Cultured, pubmed-meshheading:2142721-Female, pubmed-meshheading:2142721-Interleukin-2, pubmed-meshheading:2142721-Kinetics, pubmed-meshheading:2142721-Lymphocyte Activation, pubmed-meshheading:2142721-Lymphocyte Depletion, pubmed-meshheading:2142721-Macaca fascicularis, pubmed-meshheading:2142721-Major Histocompatibility Complex, pubmed-meshheading:2142721-Male, pubmed-meshheading:2142721-Mice, pubmed-meshheading:2142721-Mice, Inbred BALB C, pubmed-meshheading:2142721-Mice, Inbred C3H, pubmed-meshheading:2142721-Mice, Inbred C57BL, pubmed-meshheading:2142721-Spleen, pubmed-meshheading:2142721-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:2142721-Transplantation, Heterologous
pubmed:year
1990
pubmed:articleTitle
Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse.
pubmed:affiliation
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.
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