Linked Life Data

21426922

Source:http://linkedlifedata.com/resource/pubmed/id/21426922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-11
pubmed:abstractText
The excessive and prolonged nitric oxide (NO) production has been linked to various inflammatory diseases as well as tumourigenesis. On the search for anti-inflammatory and anti-cancer compounds from the medicinal plants, the methanolic extract of Euonymus alatus (Thunb.) Sieb. (Celastraceae) was found to have significant inhibitory activity on NO production in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Hence, we attempted to isolate the inhibitory constituent of E. alatus leaves and twigs on NO production. Thirteen compounds including two new glycerol derivates (1, 2), two C(13) isoprenoids (3, 4), two phenolics (5, 6) and seven flavonoids (7-13) were isolated, and the structures of 1-13 were elucidated by extensive 1D and 2D spectroscopic methods. The isolated compounds significantly inhibited NO production induced by LPS in BV2 microglia cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-6351
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1394-8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells.
pubmed:affiliation
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't