Linked Life Data

21426898

Source:http://linkedlifedata.com/resource/pubmed/id/21426898

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-18
pubmed:abstractText
Prevention of graft rejection in renal transplant recipients depends on chronic treatment with immunosuppressive agents. However, impaired immune functions and immunosurveillance may cause infection, cancer and many other problems, which subsequently compromise quality of life and survival of patients. In the present study, we assessed potential premature immune-senescence in long-term survivors of kidney transplant patients receiving immunosuppressive agents. Peripheral blood lymphocytes derived from patients had significantly shorter telomeres than those from age- and sex-matched healthy individuals. Consistent with this, lower expression of telomerase reverse transcriptase (hTERT) and telomerase activity was observed in patients' lymphocytes. The level of p16(ink4A) expression was elevated in patients' cells. Moreover, the CD8(+)/CD28(-) fraction of late-stage differentiated T cells was significantly increased in the patients. In vitro studies further showed that cyclosporine A, a widely used immunosuppressive drug in transplant patients, attenuated induction of hTERT and telomerase activation in T cells treated with the mitogenic agent concanavalin A. Taken together, immunosuppressant-mediated premature senescence of T lymphocytes occurs in renal transplant recipients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1090-2104
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
407
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
599-604
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Premature senescence of T cells in long-term survivors of renal transplantation.
pubmed:affiliation
Nursing School, Shandong University, Jinan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't