Linked Life Data

21424730

Source:http://linkedlifedata.com/resource/pubmed/id/21424730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-6-28
pubmed:abstractText
Dengue virus nonstructural protein 1 (NS1) is a glycoprotein involved in viral RNA replication. NS1 associates with host cell proteins and can be found in lipid raft domains on the host cell surface, suggesting an involvement in signal transduction events. In this work, we observed that NS1 expression in HepG2 cells increases nuclear translocation of NF-?B p65 protein, which was paralleled by DNA-protein complex formation. Luciferase assays showed an increase in NF-?B transcriptional activities in NS1-expressing cells when compared to parental cells. NS1 may enhance NF-?B function in host cells and contribute to the pathogenesis of dengue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1432-8798
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1275-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
The dengue virus nonstructural protein 1 (NS1) increases NF-?B transcriptional activity in HepG2 cells.
pubmed:affiliation
Grupo de Transdução de Sinal, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 31270-901, Brazil. brenomello@pq.cnpq.br
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't