Linked Life Data

21422916

Source:http://linkedlifedata.com/resource/pubmed/id/21422916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-22
pubmed:abstractText
There are many examples of the social facilitation of drug effects. This study focused on the pharmacological state of social partners and reports the effects of drug injections in mice whose cage mates were also, or were not, injected with the drug. The reinforcing property of methamphetamine was examined in a social context using a conditioned place preference (CPP) paradigm in mice. The paired and control-paired groups both received CPP training with a cage mate. In the paired group, both mice were either injected with methamphetamine (2 mg/kg), or with saline. The control-paired group received CPP training with their cage mate but treatment was reversed: when one mouse was injected with the drug the other was injected with saline. For the paired group, the methamphetamine injection enhanced the reinforcing effect of the drug in comparison with the mice that had undergone conventional CPP in a single-mouse design. In contrast, the control-paired group did not show such a social enhancement effect. These results suggest that sharing the same experience is crucial for the social enhancement of the methamphetamine reinforcing effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1473-5849
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Drug-social interactions in the reinforcing property of methamphetamine in mice.
pubmed:affiliation
Department of Psychology, Keio University, Minato-ku, Tokyo, Japan. swat@flet.keio.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't