Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-8-13
pubmed:abstractText
We performed a meta-analysis of 25 randomized control trials that compared endoscopic hemostasis with standard therapy for bleeding peptic ulcer. For recurrent or continued bleeding, the mean rate in control patients was 0.39, and the pooled rate difference, or reduction due to therapy, was 0.27 +/- 0.15 (95% confidence interval) (69% relative reduction). For emergency surgery, the mean rate in control patients was 0.26, and the pooled rate difference was 0.16 +/- 0.05 (62% relative reduction). Most important, for overall mortality, the mean rate in control patients was 0.10, and the pooled rate difference was 0.03 +/- 0.02 (30% relative reduction). The effects were greatest in patients with spurting or visible blood vessels and equivocal when the ulcer showed only signs of recent bleeding. We conclude that endoscopic hemostasis is clearly effective but that data were insufficient for direct comparisons between modalities. Randomized control trials to compare the different modes of endoscopic therapy should continue.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0098-7484
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
494-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:2142225-Adult, pubmed-meshheading:2142225-Aged, pubmed-meshheading:2142225-Duodenal Ulcer, pubmed-meshheading:2142225-Duodenoscopy, pubmed-meshheading:2142225-Electrocoagulation, pubmed-meshheading:2142225-Emergencies, pubmed-meshheading:2142225-Female, pubmed-meshheading:2142225-Gastroscopy, pubmed-meshheading:2142225-Hemostatic Techniques, pubmed-meshheading:2142225-Humans, pubmed-meshheading:2142225-Light Coagulation, pubmed-meshheading:2142225-Male, pubmed-meshheading:2142225-Meta-Analysis as Topic, pubmed-meshheading:2142225-Middle Aged, pubmed-meshheading:2142225-Peptic Ulcer Hemorrhage, pubmed-meshheading:2142225-Randomized Controlled Trials as Topic, pubmed-meshheading:2142225-Recurrence, pubmed-meshheading:2142225-Sclerotherapy, pubmed-meshheading:2142225-Stomach Ulcer
pubmed:year
1990
pubmed:articleTitle
Endoscopic hemostasis. An effective therapy for bleeding peptic ulcers.
pubmed:affiliation
Clinical Trials Unit, Mount Sinai School of Medicine, New York, NY.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial, Meta-Analysis