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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-6-29
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pubmed:abstractText |
Hyperglycaemia (HG) decreases intracellular tetrahydrobiopterin (BH(4)) concentrations, and this action may contribute to injury during myocardial ischaemia and reperfusion. We investigated whether increased BH(4) by cardiomyocyte-specific overexpression of the GTP cyclohydrolase (GTPCH) 1 gene rescues myocardial and mitochondrial protection by ischaemic preconditioning (IPC) during HG through a nitric oxide (NO)-dependent pathway.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6,7,8-tetrahydrobiopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Cyclohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial permeability...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
340-9
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pubmed:meshHeading |
pubmed-meshheading:21422102-Analysis of Variance,
pubmed-meshheading:21422102-Animals,
pubmed-meshheading:21422102-Biopterin,
pubmed-meshheading:21422102-Calcium,
pubmed-meshheading:21422102-Disease Models, Animal,
pubmed-meshheading:21422102-Enzyme Inhibitors,
pubmed-meshheading:21422102-GTP Cyclohydrolase,
pubmed-meshheading:21422102-Humans,
pubmed-meshheading:21422102-Hyperglycemia,
pubmed-meshheading:21422102-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:21422102-Mice,
pubmed-meshheading:21422102-Mice, Inbred C57BL,
pubmed-meshheading:21422102-Mitochondria, Heart,
pubmed-meshheading:21422102-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:21422102-Myocardial Infarction,
pubmed-meshheading:21422102-Myocardial Reperfusion Injury,
pubmed-meshheading:21422102-Myocardium,
pubmed-meshheading:21422102-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:21422102-Nitric Oxide,
pubmed-meshheading:21422102-Nitric Oxide Synthase,
pubmed-meshheading:21422102-Signal Transduction,
pubmed-meshheading:21422102-Time Factors,
pubmed-meshheading:21422102-Ventricular Function, Left
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pubmed:year |
2011
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pubmed:articleTitle |
Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia.
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pubmed:affiliation |
Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. zdge@mcw.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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