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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-5-23
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pubmed:abstractText |
MUC16 (CA125) protein is a high molecular weight mucin overexpressed in the majority of epithelial ovarian cancers (EOC) but not in the epithelium of normal ovaries suggesting that it might play a role in EOC pathogenesis. Here, we explored the phenotypic consequences of MUC16 knockdown and expression of its C-terminal domain with the aim of establishing a role for MUC16 in tumorigenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-6859
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434-43
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pubmed:meshHeading |
pubmed-meshheading:21421261-Animals,
pubmed-meshheading:21421261-CA-125 Antigen,
pubmed-meshheading:21421261-Cadherins,
pubmed-meshheading:21421261-Cell Growth Processes,
pubmed-meshheading:21421261-Cell Line, Tumor,
pubmed-meshheading:21421261-Cell Movement,
pubmed-meshheading:21421261-Down-Regulation,
pubmed-meshheading:21421261-Female,
pubmed-meshheading:21421261-Gene Knockdown Techniques,
pubmed-meshheading:21421261-Humans,
pubmed-meshheading:21421261-Membrane Proteins,
pubmed-meshheading:21421261-Mice,
pubmed-meshheading:21421261-Mice, Nude,
pubmed-meshheading:21421261-Mice, SCID,
pubmed-meshheading:21421261-Neoplasm Metastasis,
pubmed-meshheading:21421261-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:21421261-Neoplastic Stem Cells,
pubmed-meshheading:21421261-Ovarian Neoplasms,
pubmed-meshheading:21421261-Transfection,
pubmed-meshheading:21421261-Transplantation, Heterologous,
pubmed-meshheading:21421261-Vimentin
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pubmed:year |
2011
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pubmed:articleTitle |
MUC16 (CA125) regulates epithelial ovarian cancer cell growth, tumorigenesis and metastasis.
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pubmed:affiliation |
Département de Microbiologie et Infectiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, 3001 12ième Avenue Nord, Sherbrooke, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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