Source:http://linkedlifedata.com/resource/pubmed/id/21421022
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-4-25
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| pubmed:abstractText |
The ?-adrenergic blocker and 5-HT(1A) receptor antagonist pindolol has been combined with selective serotonin reuptake inhibitors (SSRIs) in patients with depressive and anxiety disorders to shorten the onset of the clinical action and/or increase the proportion of responders. The results of a previous study have shown that pindolol potentiates the panicolytic effect of paroxetine in rats submitted to the elevated T-maze (ETM). Since reported evidence has implicated the 5-HT(1A) receptors of the dorsal periaqueductal gray matter (DPAG) in the panicolytic effect of antidepressants, rats treated with pindolol (5.0mg/kg, i.p.) and paroxetine (1.5mg/kg, i.p.) received a previous intra-DPAG injection of the selective 5-HT(1A) antagonist, WAY-100635 (0.4 ?g) and were submitted to the ETM. Pretreatment with WAY-100635 reversed the increase in escape latency, a panicolytic effect, determined by the pindolol-paroxetine combination. These results implicate the 5-HT(1A) receptors of the DPAG in the panicolytic effect of the pindolol-paroxetine combination administered systemically. They also give further preclinical support for the use of this drug combination in the treatment of panic disorder.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Paroxetine,
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin 5-HT1 Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1872-7972
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
9
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| pubmed:volume |
495
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
63-6
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| pubmed:meshHeading |
pubmed-meshheading:21421022-Adrenergic beta-Antagonists,
pubmed-meshheading:21421022-Animals,
pubmed-meshheading:21421022-Drug Synergism,
pubmed-meshheading:21421022-Escape Reaction,
pubmed-meshheading:21421022-Male,
pubmed-meshheading:21421022-Maze Learning,
pubmed-meshheading:21421022-Panic,
pubmed-meshheading:21421022-Paroxetine,
pubmed-meshheading:21421022-Periaqueductal Gray,
pubmed-meshheading:21421022-Pindolol,
pubmed-meshheading:21421022-Piperazines,
pubmed-meshheading:21421022-Pyridines,
pubmed-meshheading:21421022-Rats,
pubmed-meshheading:21421022-Rats, Wistar,
pubmed-meshheading:21421022-Reaction Time,
pubmed-meshheading:21421022-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:21421022-Serotonin 5-HT1 Receptor Antagonists,
pubmed-meshheading:21421022-Serotonin Uptake Inhibitors
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| pubmed:year |
2011
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| pubmed:articleTitle |
Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze.
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| pubmed:affiliation |
Department of Pharmacology and Therapeutic, State University of Maringá, Av. Colombo, 5790 - Jardim Universitário, CEP: 87020900 Maringá, PR, Brazil.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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