|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2011-7-4
|
|
pubmed:abstractText |
Cystathionine ?-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain. Hydrogen sulfide functions as a vasodilator as well as a regulator of neuronal ion channels and multiple intracellular signaling pathways. Given the myriad effects of H(2)S, the authors hypothesized that patients possessing gain-of-function polymorphisms of the CBS gene will experience a decreased incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1933-0693
|
|
pubmed:author |
pubmed-author:BadjatiaNeerajN,
pubmed-author:ClaassenJanJ,
pubmed-author:ConnollyE SanderESJr,
pubmed-author:DeRosaPeter APA,
pubmed-author:DucruetAndrew FAF,
pubmed-author:FernandezLuisL,
pubmed-author:GrobelnyBartosz TBT,
pubmed-author:HickmanZachary LZL,
pubmed-author:KotchetkovIvan SIS,
pubmed-author:LeeKiwonK,
pubmed-author:MayerStephan ASA,
pubmed-author:NarulaReshmaR,
pubmed-author:ZachariaBrad EBE
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
115
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
101-7
|
|
pubmed:meshHeading |
pubmed-meshheading:21417705-Aged,
pubmed-meshheading:21417705-Brain Ischemia,
pubmed-meshheading:21417705-Cystathionine beta-Synthase,
pubmed-meshheading:21417705-Female,
pubmed-meshheading:21417705-Genetic Predisposition to Disease,
pubmed-meshheading:21417705-Homocysteine,
pubmed-meshheading:21417705-Humans,
pubmed-meshheading:21417705-Hydrogen Sulfide,
pubmed-meshheading:21417705-Male,
pubmed-meshheading:21417705-Middle Aged,
pubmed-meshheading:21417705-Polymorphism, Single Nucleotide,
pubmed-meshheading:21417705-Prospective Studies,
pubmed-meshheading:21417705-Risk Factors,
pubmed-meshheading:21417705-Subarachnoid Hemorrhage,
pubmed-meshheading:21417705-Time Factors,
pubmed-meshheading:21417705-Vasospasm, Intracranial
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Gain-of-function polymorphisms of cystathionine ?-synthase and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.
|
|
pubmed:affiliation |
Department of Neurosurgery, New York University Medical Center, New York, New York, USA. bartosz.grobelny@nyumc.org
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
