Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-7-27
|
| pubmed:abstractText |
To elucidate the abnormality of T cell differentiation in nude mice grafted with rat fetal thymus that develop multiple-organ-localized autoimmune diseases, we examined sequential appearance of T cell subsets and expression of TCR genes in BALB/c nude mice after grafting with fetal F344 rat thymus. We observed progressive expression of TCR gamma/delta-alpha/beta genes in the lymph node (LN) cells from 8 to 12 wk after grafting. An appreciable number of CD4+ T cells but few CD8+ T cells were detected in the LN at 8 wk after grafting. CD8+ T cells increased slowly in number by 12 wk after grafting but remained at a low level in comparison with those in nude mice 12 wk after grafting with BALB/c thymus. In correlation with an increase in the number of T cells expressing TCR alpha/beta genes, alloreactivity as assessed by MLR was increased to a normal level. However, CTL activity against alloantigens remained at a low level in the LN cells at 12 wk. At this stage, organ-specific autoimmune diseases and a high level of anti-DNA autoantibodies were detected. In these mice host-reactive T cells such as V beta 3- or V beta 11-bearing T cells were virtually eliminated in the peripheral mature T cell pool, whereas T cells maturing in the fetal rat thymus significantly proliferated in response to donor-rat stimulator cells. These results suggest that the development of the autoimmune diseases may be ascribed to an impaired maturation of CD8+ T cells but not to failure in clonal elimination of host-reactive T cells in nude mice grafted with rat thymus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Antinuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
145
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
28-35
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2141617-Animals,
pubmed-meshheading:2141617-Antibodies, Antinuclear,
pubmed-meshheading:2141617-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2141617-Autoimmune Diseases,
pubmed-meshheading:2141617-Blotting, Northern,
pubmed-meshheading:2141617-Cell Differentiation,
pubmed-meshheading:2141617-Flow Cytometry,
pubmed-meshheading:2141617-Gene Expression,
pubmed-meshheading:2141617-Immunity, Cellular,
pubmed-meshheading:2141617-Lymph Nodes,
pubmed-meshheading:2141617-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:2141617-Mice,
pubmed-meshheading:2141617-Mice, Nude,
pubmed-meshheading:2141617-RNA, Messenger,
pubmed-meshheading:2141617-Rats,
pubmed-meshheading:2141617-Receptors, Antigen, T-Cell,
pubmed-meshheading:2141617-T-Lymphocytes,
pubmed-meshheading:2141617-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2141617-Thymus Gland
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Sequential appearance of host-derived T cell subsets during differentiation in nude mice grafted with rat fetal thymus.
|
| pubmed:affiliation |
Department of Immunology, School of Medicine, Kyushu University, Fukuoka, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|