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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-4-25
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pubmed:abstractText |
Deficits in incentive motivation, the energizing of behavior in pursuit of a goal, occur in many psychiatric disorders including schizophrenia. We previously reported deficits in both cognition and incentive motivation in a transgenic mouse model of increased striatal-specific dopamine D2 receptor (D2R) density (D2R-OE mice). This molecular alteration is observed in patients with schizophrenia, making D2R-OE mice a suitable system to study the cellular and molecular mechanisms of motivation and avolition, as well as a tool for testing potential therapies against motivational deficits.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
928-35
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21414604-Affective Symptoms,
pubmed-meshheading:21414604-Aminopyridines,
pubmed-meshheading:21414604-Analysis of Variance,
pubmed-meshheading:21414604-Animals,
pubmed-meshheading:21414604-Conditioning, Operant,
pubmed-meshheading:21414604-Corpus Striatum,
pubmed-meshheading:21414604-Disease Models, Animal,
pubmed-meshheading:21414604-Gene Expression,
pubmed-meshheading:21414604-Indoles,
pubmed-meshheading:21414604-Mice,
pubmed-meshheading:21414604-Mice, Transgenic,
pubmed-meshheading:21414604-Motivation,
pubmed-meshheading:21414604-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:21414604-Receptors, Dopamine D2,
pubmed-meshheading:21414604-Reward,
pubmed-meshheading:21414604-Schizophrenia,
pubmed-meshheading:21414604-Serotonin 5-HT2 Receptor Antagonists,
pubmed-meshheading:21414604-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia.
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pubmed:affiliation |
Department of Psychiatry, Columbia University, New York, New York 10032, USA. es534@columbia.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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