|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2011-5-13
|
|
pubmed:abstractText |
Salvinorin A (SA) is the principal active ingredient of Salvia divinorum, with an established inhibitory action on gastrointestinal (GI) transit and colonic ion transport in mice. Under normal conditions, the effects of SA are mediated by kappa opioid (KOR) and cannabinoid (CB1 and CB2) receptors. However, the role of SA in pathophysiological conditions remains unresolved. The aim of this study was to characterize the in vitro and in vivo effects of SA on mouse ileum after endotoxin challenge.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1365-2982
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
583-e212
|
|
pubmed:meshHeading |
pubmed-meshheading:21414104-Animals,
pubmed-meshheading:21414104-Defecation,
pubmed-meshheading:21414104-Diterpenes, Clerodane,
pubmed-meshheading:21414104-Endotoxins,
pubmed-meshheading:21414104-Gastrointestinal Motility,
pubmed-meshheading:21414104-Ileum,
pubmed-meshheading:21414104-Intestinal Mucosa,
pubmed-meshheading:21414104-Ion Transport,
pubmed-meshheading:21414104-Male,
pubmed-meshheading:21414104-Mice,
pubmed-meshheading:21414104-Muscle, Smooth,
pubmed-meshheading:21414104-Muscle Contraction,
pubmed-meshheading:21414104-Nitrates,
pubmed-meshheading:21414104-Nitric Oxide,
pubmed-meshheading:21414104-Nitric Oxide Synthase Type II,
pubmed-meshheading:21414104-Nitrites
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum.
|
|
pubmed:affiliation |
Division of Gastroenterology, Department of Medicine, Snyder Institute of Infection, Immunity and Inflammation (III), University of Calgary, Calgary, AB, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
