Linked Life Data

21413988

Source:http://linkedlifedata.com/resource/pubmed/id/21413988

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-3
pubmed:abstractText
In this study, single and double-labeling immunofluorescence histochemistry, Western blot and real-time polymerase chain reaction were used to study the expression of P2Y(6) receptors in developing mouse skeletal muscle and during injury and repair. The results show that P2Y(6) receptor immunoreactive (ir) cells were first detected in the dermamyotome at embryonic (E) day 9. The number and immunostaining intensity of the P2Y(6) receptor-ir cells increased from E9 to E13, but decreased from E15 to postnatal day 60 in the developing skeletal muscle system. The expression levels of P2Y(6) receptor protein and mRNA increased rapidly from 1 to 5 days after skeletal muscle injury and then decreased almost to the control level from 7 to 10 days, at the beginning of regeneration. P2Y(6) receptor-immunoreactivity was mainly localized to the ends of single myoblasts and myotube processes in the developing and injury-repair skeletal muscle tissues. These data suggest that the P2Y(6) receptor may be involved in the development and regeneration of skeletal muscle, especially in the migration and extension of the myoblast and myotube in developing and regenerating skeletal muscle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1469-7580
pubmed:author
pubmed:copyrightInfo
© 2011 The Authors. Journal of Anatomy © 2011 Anatomical Society of Great Britain and Ireland.
pubmed:issnType
Electronic
pubmed:volume
218
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-51
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair.
pubmed:affiliation
Department of Otolaryngology & Head and Neck Surgery, Changhai Hospital, Shanghai, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't