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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-7-24
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pubmed:abstractText |
The susceptibility of laboratory mice to Borrelia burgdorferi was evaluated for selected genotypes and ages. C3H/He, SWR, C57BL/6, SJL, and BALB/c mice inoculated at age 3 days developed uniformly severe polyarthritis at 30 days after intraperitoneal inoculation. Mice inoculated at age 3 weeks also developed polyarthritis, but severity was influenced by genotype, with C3H/He and SWR mice the most severely affected. Susceptible strains developed higher IgG ELISA antibody titers to B. burgdorferi than did resistant mice. Adult (12 weeks) C3H/He mice were also susceptible, but arthritis was not as severe as in those inoculated at age 3 weeks. SKH (hairless) mice developed polyarthritis but not skin disease when inoculated intradermally. Carditis occurred frequently among C3H/He, BALB/c, and hairless mice and in some SWR mice but not in C57BL/6 or SJL mice. This study demonstrates that severity of Lyme borreliosis is age- and genotype-dependent and that laboratory mice are a potentially valuable model.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2141344-Animals,
pubmed-meshheading:2141344-Antibodies, Bacterial,
pubmed-meshheading:2141344-Borrelia burgdorferi Group,
pubmed-meshheading:2141344-Disease Models, Animal,
pubmed-meshheading:2141344-Disease Susceptibility,
pubmed-meshheading:2141344-Genotype,
pubmed-meshheading:2141344-Immunoglobulin G,
pubmed-meshheading:2141344-Lyme Disease,
pubmed-meshheading:2141344-Mice,
pubmed-meshheading:2141344-Mice, Hairless,
pubmed-meshheading:2141344-Mice, Inbred BALB C,
pubmed-meshheading:2141344-Mice, Inbred C3H,
pubmed-meshheading:2141344-Mice, Inbred C57BL,
pubmed-meshheading:2141344-Mice, Inbred Strains,
pubmed-meshheading:2141344-Specific Pathogen-Free Organisms
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pubmed:year |
1990
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pubmed:articleTitle |
Lyme borreliosis in selected strains and ages of laboratory mice.
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pubmed:affiliation |
Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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