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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1990-7-23
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pubmed:abstractText |
Fifty-one radiation-induced murine osteosarcomas were investigated for alterations in c-myc gene structure and c-myc expression. Amplification of c-myc was found in 30% of BALB/c tumors and 13% of NMRI tumors. A region of common proviral integration, Mlvi-1, localized on the same region on chromosome 15, was amplified concomitantly. Multiple copies of both loci were localized on double minutes. Three of the tumors with c-myc amplification also showed rearrangements of the c-myc gene region. One of these rearrangements included the 5' and 3'-flanking sequences and the noncoding part of the third exon. Repetitive sequences were found in the 5' region of the c-myc gene, and the 3' flanking region was substituted by sequences normally present in a more distant part of chromosome 15. Increased levels of c-myc transcripts of apparently normal size were found in tumors carrying amplified c-myc sequences. Abnormally high expression of c-myc in some tumors was correlated with an early stage of osteogenic differentiation, suggesting the involvement of the c-myc gene in the control of the osteogenic differentiation of transformed cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4146-53
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2141296-Animals,
pubmed-meshheading:2141296-Chromosome Mapping,
pubmed-meshheading:2141296-Female,
pubmed-meshheading:2141296-Gene Amplification,
pubmed-meshheading:2141296-Gene Rearrangement,
pubmed-meshheading:2141296-Genomic Library,
pubmed-meshheading:2141296-Karyotyping,
pubmed-meshheading:2141296-Mice,
pubmed-meshheading:2141296-Mice, Inbred BALB C,
pubmed-meshheading:2141296-Neoplasms, Radiation-Induced,
pubmed-meshheading:2141296-Oncogenes,
pubmed-meshheading:2141296-Osteopontin,
pubmed-meshheading:2141296-Osteosarcoma,
pubmed-meshheading:2141296-Proto-Oncogene Proteins,
pubmed-meshheading:2141296-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:2141296-Proto-Oncogene Proteins c-mos,
pubmed-meshheading:2141296-RNA, Neoplasm,
pubmed-meshheading:2141296-Sialoglycoproteins
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pubmed:year |
1990
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pubmed:articleTitle |
Amplification and rearrangement of c-myc in radiation-induced murine osteosarcomas.
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pubmed:affiliation |
GSF-Abteilung für Molekulare Zellpathologie, Neuherberg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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