Source:http://linkedlifedata.com/resource/pubmed/id/21411754
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2011-7-15
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pubmed:abstractText |
Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site in their promoters, and their expression was shown to be driven by IRF-1, indicating this subset was induced directly by viral infection by IRF-1. IRF-1 and -7 protein expression was enriched in HIV p24 antigen-positive DCs. A HIV deletion mutant with the IRF-1 binding site deleted from the long terminal repeat showed reduced growth kinetics. Early and persistent induction of IRF-1 was coupled with sequential transient up-regulation of its 2 inhibitors, IRF-8, followed by IRF-2, suggesting a mechanism for IFN inhibition. HIV-1 mutants with Vpr deleted induced IFN, showing that Vpr is inhibitory. However, HIV IFN inhibition was mediated by failure of IRF-3 activation rather than by its degradation, as in T cells. In contrast, herpes simplex virus type 2 markedly induced IFN? and a broader range of ISGs to higher levels, supporting the hypothesis that HIV-1 specifically manipulates the induction of IFN and ISGs to enhance its noncytopathic replication in DCs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:ChurchillMelissaM,
pubmed-author:CummingHelenH,
pubmed-author:CunninghamAnthony LAL,
pubmed-author:DonaghyHeatherH,
pubmed-author:GaleMichaelMJr,
pubmed-author:GrayLachlanL,
pubmed-author:HarmanAndrew NAN,
pubmed-author:HertzogPaulP,
pubmed-author:JonesKateK,
pubmed-author:LaiJoeyJ,
pubmed-author:MakJohnsonJ,
pubmed-author:MarsdenValerieV,
pubmed-author:MercierSarahS,
pubmed-author:NasrNajlaN,
pubmed-author:RustagiArjunA,
pubmed-author:SamarajiwaShamithS,
pubmed-author:TurvilleStuartS
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
298-308
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pubmed:meshHeading |
pubmed-meshheading:21411754-Cells, Cultured,
pubmed-meshheading:21411754-Dendritic Cells,
pubmed-meshheading:21411754-Down-Regulation,
pubmed-meshheading:21411754-Gene Expression Profiling,
pubmed-meshheading:21411754-Gene Expression Regulation,
pubmed-meshheading:21411754-HIV Infections,
pubmed-meshheading:21411754-HIV-1,
pubmed-meshheading:21411754-Humans,
pubmed-meshheading:21411754-Interferon Regulatory Factor-1,
pubmed-meshheading:21411754-Interferon Type I,
pubmed-meshheading:21411754-Microarray Analysis,
pubmed-meshheading:21411754-Promoter Regions, Genetic,
pubmed-meshheading:21411754-Sequence Analysis, DNA,
pubmed-meshheading:21411754-Signal Transduction,
pubmed-meshheading:21411754-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.
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pubmed:affiliation |
Centre for Virus Research, Westmead Millennium Institute, Westmead, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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