| pubmed-article:21411560 | pubmed:abstractText | Overexposure of the fetus to glucocorticoids early in gestation is detrimental to fetal development. Glucocorticoid concentrations in the fetal circulation are kept low by 11?-hydroxysteroid dehydrogenase type 2 (11?-HSD2, encoded by HSD11B2) in the placental syncytiotrophoblasts. However, cytotrophoblasts, the progenitors of syncytiotrophoblasts, express low levels of 11?-HSD2. Here we studied the molecular mechanisms underlying 11?-HSD2 induction upon syncytialization. | lld:pubmed |
