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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2011-5-23
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pubmed:abstractText |
Overexposure of the fetus to glucocorticoids early in gestation is detrimental to fetal development. Glucocorticoid concentrations in the fetal circulation are kept low by 11?-hydroxysteroid dehydrogenase type 2 (11?-HSD2, encoded by HSD11B2) in the placental syncytiotrophoblasts. However, cytotrophoblasts, the progenitors of syncytiotrophoblasts, express low levels of 11?-HSD2. Here we studied the molecular mechanisms underlying 11?-HSD2 induction upon syncytialization.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1945-7197
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E899-907
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pubmed:meshHeading |
pubmed-meshheading:21411560-11-beta-Hydroxysteroid Dehydrogenase Type 2,
pubmed-meshheading:21411560-Analysis of Variance,
pubmed-meshheading:21411560-Blotting, Western,
pubmed-meshheading:21411560-Cells, Cultured,
pubmed-meshheading:21411560-Chromatin Immunoprecipitation,
pubmed-meshheading:21411560-Cyclic AMP,
pubmed-meshheading:21411560-DNA Methylation,
pubmed-meshheading:21411560-Female,
pubmed-meshheading:21411560-Humans,
pubmed-meshheading:21411560-Immunohistochemistry,
pubmed-meshheading:21411560-Placenta,
pubmed-meshheading:21411560-Pregnancy,
pubmed-meshheading:21411560-Promoter Regions, Genetic,
pubmed-meshheading:21411560-RNA, Messenger,
pubmed-meshheading:21411560-RNA, Small Interfering,
pubmed-meshheading:21411560-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21411560-Signal Transduction,
pubmed-meshheading:21411560-Sp1 Transcription Factor,
pubmed-meshheading:21411560-Trophoblasts
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pubmed:year |
2011
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pubmed:articleTitle |
The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.
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pubmed:affiliation |
School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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