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rdf:type |
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lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0003591,
umls-concept:C0004153,
umls-concept:C0005516,
umls-concept:C0021753,
umls-concept:C0026809,
umls-concept:C0392756,
umls-concept:C0599894,
umls-concept:C1522492,
umls-concept:C1533691,
umls-concept:C2936350
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pubmed:issue |
2
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pubmed:dateCreated |
2011-6-7
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pubmed:abstractText |
Atherosclerosis is a condition that is increasingly contributing to worldwide mortality through complications such as stroke and myocardial infarction. IL-1? plays multiple direct, local roles in the formation and stability of the atheroma by eliciting the production of additional cytokines and proteolytic enzymes from macrophages, endothelial cells (EC) and smooth muscle cells (SMC). We therefore tested whether an anti-IL-1? antibody, XOMA 052, might inhibit the secretion of pro-atherogenic cytokines from macrophages in vitro and affect a positive outcome in the Apolipoprotein E-deficient mouse (ApoE(-/-)) model of atherosclerosis in vivo.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
216
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-20
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pubmed:meshHeading |
pubmed-meshheading:21411094-Animals,
pubmed-meshheading:21411094-Antibodies, Monoclonal,
pubmed-meshheading:21411094-Apolipoproteins E,
pubmed-meshheading:21411094-Atherosclerosis,
pubmed-meshheading:21411094-Biological Markers,
pubmed-meshheading:21411094-Body Weight,
pubmed-meshheading:21411094-Coculture Techniques,
pubmed-meshheading:21411094-Cytokines,
pubmed-meshheading:21411094-Endothelial Cells,
pubmed-meshheading:21411094-Humans,
pubmed-meshheading:21411094-Interleukin-1beta,
pubmed-meshheading:21411094-Lipids,
pubmed-meshheading:21411094-Macrophages,
pubmed-meshheading:21411094-Mice,
pubmed-meshheading:21411094-Mice, Inbred C57BL,
pubmed-meshheading:21411094-Mice, Transgenic,
pubmed-meshheading:21411094-Myocytes, Smooth Muscle,
pubmed-meshheading:21411094-Plaque, Atherosclerotic
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pubmed:year |
2011
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pubmed:articleTitle |
Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice.
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pubmed:affiliation |
Preclinical Research, XOMA (US) LLC, 2910 Seventh Street, Berkeley, CA 94710, USA. bhaskar@xoma.com
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pubmed:publicationType |
Journal Article,
In Vitro
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