Linked Life Data

2140792

Source:http://linkedlifedata.com/resource/pubmed/id/2140792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-7-11
pubmed:abstractText
The neuropeptide beta-endorphin can modulate the response of T and B cells to mitogenic or antigenic stimulation. In the present report we describe a novel mechanism by which beta-endorphin can interfere with T cell activation. It is shown here that beta-endorphin can modulate the phorbol ester-induced phosphorylation of the gamma chain of the CD3 complex. The effect of beta-endorphin is dose dependent and appears to be mediated via interaction of beta-endorphin with an opiate receptor on lymphocytes. Evidence is presented that the modulatory effect of beta-endorphin is specific for the phosphorylation of the CD3 gamma chain. beta-Endorphin does not affect the phosphorylation of total cell protein, nor does it have any effect on the phosphorylation of the CD4 determinant on T cells. The possible consequence of a change in CD3 gamma chain phosphorylation is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
943-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
The phosphorylation of the CD3 gamma chain of T lymphocytes is modulated by beta-endorphin.
pubmed:affiliation
Department of Pediatric Immunology, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, The Netherlands.
pubmed:publicationType
Journal Article