Source:http://linkedlifedata.com/resource/pubmed/id/21406395
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2011-3-16
|
| pubmed:abstractText |
Several lines of data have suggested a possible link between the indoleamine 2,3-dioxygenase (IDO)-like protein IDO2 and cancer. First, IDO2 expression has been described in human tumors, including renal, gastric, colon, and pancreatic tumors. Second, the apparent selective inhibition of IDO2 by the D stereoisomer of the IDO blocker 1-methyl-tryptophan (1MT), which tends to be more active than the L-isomer in a variety of biological assays for IDO function, suggests that IDO2 may be important to sustain immune escape and growth of tumors. Especially, D-1MT heightens chemotherapeutic efficacy in mouse models of cancer in a nontoxic fashion. Here, we describe the immunogenicity of IDO2 by showing the presence of spontaneous cytotoxic T-cell reactivity against IDO2 in peripheral blood of both healthy donors and cancer patients. Furthermore, we show that these IDO2-specific T cells are cytotoxic effector cells that recognize and kill tumor cells. Our data suggest that IDO2 might be a useful target for anticancer immunotherapeutic strategies.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1538-7445
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| pubmed:author | |
| pubmed:copyrightInfo |
©2011 AACR
|
| pubmed:issnType |
Electronic
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| pubmed:day |
15
|
| pubmed:volume |
71
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2038-44
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| pubmed:meshHeading |
pubmed-meshheading:21406395-Amino Acid Sequence,
pubmed-meshheading:21406395-Carcinoma, Renal Cell,
pubmed-meshheading:21406395-Cell Line, Tumor,
pubmed-meshheading:21406395-Cells, Cultured,
pubmed-meshheading:21406395-Cytotoxicity, Immunologic,
pubmed-meshheading:21406395-Flow Cytometry,
pubmed-meshheading:21406395-HCT116 Cells,
pubmed-meshheading:21406395-HLA-A2 Antigen,
pubmed-meshheading:21406395-Humans,
pubmed-meshheading:21406395-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:21406395-K562 Cells,
pubmed-meshheading:21406395-Kidney Neoplasms,
pubmed-meshheading:21406395-Melanoma,
pubmed-meshheading:21406395-Neoplasms,
pubmed-meshheading:21406395-Peptides,
pubmed-meshheading:21406395-Protein Binding,
pubmed-meshheading:21406395-RNA Interference,
pubmed-meshheading:21406395-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21406395-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2.
|
| pubmed:affiliation |
Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|