Source:http://linkedlifedata.com/resource/pubmed/id/21406174
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2011-3-25
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| pubmed:abstractText |
A close relationship between tumor angiogenesis, growth, and carcinomatosis has been observed. Netrin-4 (NT-4) has been shown to regulate angiogenic responses. We aimed to examine the effects of NT-4 on colon tumor angiogenesis, growth, and carcinomatosis. We showed that NT-4 was expressed in human colon cancer cells (LS174). A 20-fold increase in NT-4 expression was stably induced by NT-4 pcDNA in LS174 cells. In vivo, a Matrigel angiogenesis assay showed that NT-4 overexpression altered vascular endothelial growth factor (VEGF)/basic fibroblast growth factor-induced angiogenesis. In nude mice with LS174 xenografts, NT-4 overexpression inhibited tumor angiogenesis and growth. In addition, these NT-4-involved inhibitory effects were associated with decreased tumor cell proliferation and increased tumor cell apoptosis. Using an orthotopic peritoneal carcinomatosis model, we demonstrated that NT-4 overexpression decreased colorectal cancer carcinomatosis. Moreover, carcinomatosis-related ascites formation was significantly decreased in mice transplanted with NT-4 LS174 cells versus control LS174 cells. The antiangiogenic activity of NT-4 was probably mediated by binding to its receptor neogenin. Netrin-4 had a direct effect on neither in vitro apoptosis and proliferation of cultured LS174 cells nor the VEGF-induced acute increase in vascular permeability in vivo. We propose that NT-4 overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect, underlying the potential therapeutic interest in NT-4 in the treatment of colorectal cancer growth and carcinomatosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/NTN4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1525-2191
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
178
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1861-9
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| pubmed:meshHeading |
pubmed-meshheading:21406174-Angiogenesis Inhibitors,
pubmed-meshheading:21406174-Animals,
pubmed-meshheading:21406174-Carcinoma,
pubmed-meshheading:21406174-Cell Line, Tumor,
pubmed-meshheading:21406174-Collagen,
pubmed-meshheading:21406174-Colorectal Neoplasms,
pubmed-meshheading:21406174-Disease Progression,
pubmed-meshheading:21406174-Drug Combinations,
pubmed-meshheading:21406174-Female,
pubmed-meshheading:21406174-Gene Expression Profiling,
pubmed-meshheading:21406174-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21406174-Humans,
pubmed-meshheading:21406174-Laminin,
pubmed-meshheading:21406174-Mice,
pubmed-meshheading:21406174-Mice, Nude,
pubmed-meshheading:21406174-Neoplasm Transplantation,
pubmed-meshheading:21406174-Neovascularization, Pathologic,
pubmed-meshheading:21406174-Nerve Growth Factors,
pubmed-meshheading:21406174-Proteoglycans
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| pubmed:year |
2011
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| pubmed:articleTitle |
Netrin-4 delays colorectal cancer carcinomatosis by inhibiting tumor angiogenesis.
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| pubmed:affiliation |
INSERM U965 (Paris 7 University), Hôpital Lariboisière, Paris, France.
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| pubmed:publicationType |
Journal Article
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