Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-30
pubmed:abstractText
Boswellic acids are pentacyclic triterpenes, which are produced in plants belonging to the genus Boswellia. Boswellic acids appear in the resin exudates of the plant and it makes up 25-35% of the resin. ?-boswellic acid, 11-keto-?-boswellic acid and acetyl-11-keto-?-boswellic acid have been implicated in apoptosis of cancer cells, particularly that of brain tumors and cells affected by leukemia or colon cancer. These molecules are also associated with potent antimicrobial activities. The present study describes the antimicrobial activities of boswellic acid molecules against 112 pathogenic bacterial isolates including ATCC strains. Acetyl-11-keto-?-boswellic acid (AKBA), which exhibited the most potent antibacterial activity, was further evaluated in time kill studies, postantibiotic effect (PAE) and biofilm susceptibility assay. The mechanism of action of AKBA was investigated by propidium iodide uptake, leakage of 260 and 280 nm absorbing material assays.
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-2180
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
54
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-?-boswellic acid from Boswellia serrata.
pubmed:affiliation
Microbiology Unit, Indian Institute of Integrative Medicine (CSIR), Sanatnagar, Srinagar, 190005, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't