Linked Life Data

21405945

Source:http://linkedlifedata.com/resource/pubmed/id/21405945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-2
pubmed:abstractText
We investigated the molecular mechanisms underlying the cytotoxic effect of Temozolomide (TMZ) in both O(6)-methylguanine-DNA methyl transferase (MGMT) depleted as well as undepleted glioblastoma cell lines. Since TMZ is used in clinics in combination with radiotherapy, we also studied the effects of TMZ in combination with ionising radiation (IR).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating, http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases, http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes, http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta, http://linkedlifedata.com/resource/pubmed/chemical/temozolomide
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1362-3095
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
518-33
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:21405945-Antineoplastic Agents, Alkylating, pubmed-meshheading:21405945-Apoptosis, pubmed-meshheading:21405945-Brain Neoplasms, pubmed-meshheading:21405945-Cell Cycle, pubmed-meshheading:21405945-Cell Line, Tumor, pubmed-meshheading:21405945-DNA Modification Methylases, pubmed-meshheading:21405945-DNA Repair Enzymes, pubmed-meshheading:21405945-Dacarbazine, pubmed-meshheading:21405945-Flow Cytometry, pubmed-meshheading:21405945-Glioblastoma, pubmed-meshheading:21405945-Glycogen Synthase Kinase 3, pubmed-meshheading:21405945-Humans, pubmed-meshheading:21405945-Proto-Oncogene Proteins c-akt, pubmed-meshheading:21405945-Proto-Oncogene Proteins c-myc, pubmed-meshheading:21405945-RNA, Small Interfering, pubmed-meshheading:21405945-Radiation, Ionizing, pubmed-meshheading:21405945-Tumor Suppressor Proteins
pubmed:year
2011
pubmed:articleTitle
Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.
pubmed:affiliation
Centro Ricerca S. Pietro, Fatebenefratelli Hospital, Via Cassia 600, Rome, Italy.
pubmed:publicationType
Journal Article