|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003501,
umls-concept:C0004153,
umls-concept:C0006560,
umls-concept:C0009498,
umls-concept:C0011164,
umls-concept:C0027950,
umls-concept:C0205217,
umls-concept:C0205263,
umls-concept:C0332307,
umls-concept:C0333562,
umls-concept:C1524003,
umls-concept:C2756983
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2011-3-16
|
|
pubmed:abstractText |
Recent studies have indicated that atherosclerosis-like changes are involved in the pathogenesis of aortic valve stenosis. Increased blood and valve tissue levels of C-reactive protein (CRP) have been reported in patients with aortic valve disease, although the different pathological conditions involved were not analyzed. The study aim was to monitor the deposition of CRP, its activator sPLA2-IIA and its effector complement, and the subsequent influx of neutrophilic granulocytes in degenerative and atherosclerotic aortic valves.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0966-8519
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
29-36
|
|
pubmed:meshHeading |
pubmed-meshheading:21404895-Adult,
pubmed-meshheading:21404895-Aged,
pubmed-meshheading:21404895-Aged, 80 and over,
pubmed-meshheading:21404895-Aortic Valve,
pubmed-meshheading:21404895-Aortic Valve Stenosis,
pubmed-meshheading:21404895-Atherosclerosis,
pubmed-meshheading:21404895-Autopsy,
pubmed-meshheading:21404895-C-Reactive Protein,
pubmed-meshheading:21404895-Complement C3d,
pubmed-meshheading:21404895-Female,
pubmed-meshheading:21404895-Group II Phospholipases A2,
pubmed-meshheading:21404895-Humans,
pubmed-meshheading:21404895-Image Processing, Computer-Assisted,
pubmed-meshheading:21404895-Immunohistochemistry,
pubmed-meshheading:21404895-Inflammation Mediators,
pubmed-meshheading:21404895-Male,
pubmed-meshheading:21404895-Middle Aged,
pubmed-meshheading:21404895-Netherlands,
pubmed-meshheading:21404895-Neutrophil Infiltration
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx.
|
|
pubmed:affiliation |
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands. k.kupreishvili@vumc.nl
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
