Linked Life Data

21402235

Source:http://linkedlifedata.com/resource/pubmed/id/21402235

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-3-15
pubmed:abstractText
The initial therapy for patients with pulmonary embolism who are haemodynamically stable relies on antithrombotic treatment. The aim of anticoagulant treatment is to prevent any thrombus extension or recurrence, with revascularization dependent on the fibrinolytic system. Current treatment is biphasic, with parenteral heparin or derivatives (low molecular weight heparins and fondaparinux) followed by oral vitamin K antagonists. Although these treatments are efficient, they suffer from some limitations including parenteral administration and the need for surveillance and monitoring. Use of low molecular weight heparins or fondaparinux is recommended in French guidelines, but unfractionated heparin still has an important role in some specific situations such as severe renal insufficiency, around the time of surgery and where there is a high risk of bleeding. The next generation of anticoagulants will soon be licensed for treatment in pulmonary embolism and may well replace heparin and/or vitamin K antagonists for the majority of patients, although "older" treatments will always be requested in some specific situations.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1776-2588
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 SPLF. Published by Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-26
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
[Initial antithrombotic therapy for pulmonary embolism].
pubmed:affiliation
Groupe de recherche sur la thrombose, université de Saint-Étienne, Saint-Étienne, France. laurent.bertoletti@gmail.com
pubmed:publicationType
Journal Article, English Abstract, Review